Hyaluronic acid
How it works and where it’s used
Diacerein
Supporting joint health by targeting inflammation
What is diacerein?
Diacerein is a long-established treatment option for the symptoms of knee and hip osteoarthritis. Obtained from Aloe Vera plants, it works differently from medicines designed to provide rapid pain relief. Instead, diacerein acts gradually over time by targeting inflammatory processes involved in joint pain, stiffness and cartilage changes.
This slow-acting approach means that its benefits may develop progressively with continued treatment, helping to support long-term symptom management and improve joint function in people living with osteoarthritis.1,2
Diacerein works by blocking the action of a substance in the body called interleukin-1 beta (IL-1β), which plays a key role in causing inflammation and joint damage in osteoarthritis. By reducing the production and activity of IL-1β and its receptors in cartilage cells, it helps to slow down the processes that lead to inflammation and cartilage breakdown.1
Diacerein
Oral inhibition of interleukin-1 in the treatment of osteoarthritis
Osteoarthritis
A common joint condition linked to gradual cartilage breakdown, often causing pain and stiffness
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References
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Pavelka K, Bruyère O, Cooper C, et al. Diacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEO. Drugs Aging. 2016;33(2):75–85.
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Fidelix TS, Macedo CR, Maxwell LJ, et al. Diacerein for osteoarthritis. Cochrane Database Syst Rev. 2014;2014(2):CD005117
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Pelletier JP, Yaron M, Haraoui B, et al. Efficacy and safety of diacerein in osteoarthritis of the knee: a double-blind, placebo-controlled trial. The Diacerein Study Group. Arthritis Rheum. 2000;43(10):2339–2348.
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Nguyen M, Dougados M, Berdah L, Amor B. Diacerhein in the treatment of osteoarthritis of the hip. Arthritis Rheum. 1994;37(4):529–536.
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Zheng WJ, Tang FL, Li J, et al. Evaluation of efficacy and safety of diacerein in knee osteoarthritis in Chinese patients. Chin Med Sci J. 2006;21(2):75–80.
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Dougados M, Nguyen M, Berdah L, et al. Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial. Arthritis Rheum. 2001;44(11):2539–2547.