Musculoskeletal Disorders
Explore impacts on movement and quality of life
Neurology
Driving progress against neurodegenerative diseases and complex neurological pain.
Neurological health: addressing complex challenges
Neurological and neurodegenerative diseases represent profoundly significant challenges and burdens to global health.1 Conditions such as Parkinson’s disease, stroke, spinal cord injury, chronic pain, and Huntington’s disease can have a devastating impact on patients and their families – affecting mobility, cognition, independence, and quality of life.2-4
At TRB, we are committed to advancing scientific understanding and developing therapeutic approaches that protect and restore neurological function, with the goal of improving outcomes for those affected by these complex disorders.
Expertise in neuroprotection and repair
For more than two decades, TRB has been actively engaged in research and development in neurology, focusing on neurodegenerative diseases and neuronal repair. Our work has included extensive study into GM1 ganglioside, a naturally occurring molecule known for its neurotrophic, neuroprotective, and neurorestorative properties.5–7
By manufacturing and commercialising GM1 since the early 1990s, we have gained unique experience in its potential therapeutic roles. Today, we continue to investigate new indications, mechanisms of action, and delivery approaches to optimise its safety and efficacy.
Driving research and collaboration
Beyond developing treatments, TRB is committed to advancing the scientific dialogue in neurology. Through our sponsorship of international seminars and workshops in neuroscience, we bring together experts to exchange knowledge and explore new strategies for understanding and managing neurodegenerative disorders.
These initiatives demonstrate our dedication to collaboration, scientific integrity, and progress – fostering an environment where innovation can thrive.
Looking ahead: a vision for the future of neurological care
As our understanding of the nervous system evolves, TRB remains dedicated to pioneering research in neuroprotection and regeneration, with the ambition to expand treatment options for both common and rare neurological conditions.
GM1 ganglioside
A complex lipid found in nerve cell membranes, involved in membrane dynamics and signalling
References
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1. Wang S, Jiang Y, Yang A, et al. The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need. Aging and disease. 2024;16(5):2937–2952.
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Mollà-Casanova S, Pedrero-Sánchez J, Inglés M, et al. Impact of Parkinson’s Disease on Functional Mobility at Different Stages. Frontiers in Aging Neuroscience. 2022;14:935841.
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Pérez-Pérez J, García-López S, Valle TF, et al. Huntington Disease Health Related Quality of Life, Function and Well Being: The Patient’s Perspective. Neurology and Therapy. 2024;14:99–115.
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Dueñas M, Ojeda B, Salazar A, et al. A review of chronic pain impact on patients, their social environment and the health care system. Journal of Pain Research. 2016;9:457–467.
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Yanagisawa K. GM1 ganglioside and Alzheimer’s disease. Glycoconj J. 2015;32(3-4):105-12.
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Schneider JS, Gollomp SM, Sendek S, et al. A randomized, controlled, delayed start trial of GM1 ganglioside in treated Parkinson’s disease patients. J Neurol Sci. 2013;324(1-2):140-8.